2-Fluorotoluene → 1-Benzyl-4-(o-tolyloxy)piperidine
Reaktionsgleichung
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH3:22]>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
By following the manipulative procedure described in Example 1(a), 21.0 g of 1-benzyl-4-piperidinol and 24.0 g of o-fluorotoluene produces a yellow oil fraction which boils at 161°-163° C., 0.09 mm. This oil solidifies slowly upon standing and is recrystallized from petroleum ether (b.p. 30°-60°) to give white crystals of 1-benzyl-4-(o-tolyloxy) piperidine.
Aufarbeitung
- customproduces a yellow oil fraction which boils at 161°-163° C., 0.09 mm
- customis recrystallized from petroleum ether (b.p. 30°-60°)
Quellen und Nachweise
- ORD-Eintrag