[NH:1]1[CH2:3][CH2:2]1.C(=O)([O-])O.[Na+].[F:9][C:10]1[CH:18]=[CH:17][C:13]([C:14](Cl)=[O:15])=[C:12]([N+:19]([O-:21])=[O:20])[CH:11]=1.[OH-].[Na+]>ClC(Cl)Cl>[F:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([N:1]2[CH2:3][CH2:2]2)=[O:15])=[C:12]([N+:19]([O-:21])=[O:20])[CH:11]=1To a mixture of 21.6 parts of aziridine and 37.8 parts of sodium hydrogen carbonate is added dropwise a solution of 85 parts of 4-fluoro-2-nitro benzoyl chloride in 75 parts of trichloromethane while stirring vigorously at 0° C. Upon completion, stirring vigorously is continued for 30 minutes without cooling. After warming to 25° C, the reaction mixture is adjusted to pH 8 with a diluted sodium hydroxide solution. The product is extracted three times with trichloromethane. The combined extracts are washed with water, dried filtered and evaporated, yielding 75 parts of 1-(4-fluoro-2-nitrobenzoyl)aziridine as a residue.
Wird geladen…
