Benzene → HCID 21428866, Verbindung

HRID 437624Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 437624
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]2[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[C:13]1([N:19]2[C:23]3([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:22](=[O:29])[NH:21][CH2:20]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1C=CC=CC=1>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:10][CH2:9][N:26]2[CH2:25][CH2:24][C:23]3([N:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH2:20][NH:21][C:22]3=[O:29])[CH2:28][CH2:27]2)=[O:7])=[CH:11][CH:12]=1

Komponenten

5

Edukt 3

HCID 241BenzeneHCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 2450271-(4-Chlorobenzoyl)aziridine

Produkt 1

HCID 21428866HCID 21428866, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1.82 parts of 1-(4-chlorobenzoyl)aziridine, 2.32 parts of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one, 10.8 parts of benzene an 1.6 parts of methanol is stirred and refluxed for 1.50 hours. The reaction mixture is cooled and upon scratching, the product solidifies. It is filtered off, washed with benzene and crystallized from 2-propanol, yielding 1.53 parts of 4-chloro-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]benzamide; mp. 200.6° C.

Aufarbeitung

  1. temperaturerefluxed for 1.50 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationIt is filtered off
  4. washwashed with benzene
  5. customcrystallized from 2-propanol

Quellen und Nachweise

ORD-Eintrag
ord-8f8b1ee3f79b4e99b20ada9df39c2347
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031226

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