Hydrogen Peroxide → 5-Amino-3-isopropylisothiazole-4-carbonitrile

HRID 437710Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 437710
OO.[NH2:3][C:4]([CH:11]([CH3:13])[CH3:12])=[C:5]([C:9]#[N:10])[C:6](=[S:8])[NH2:7]>C(O)C>[NH2:7][C:6]1[S:8][N:3]=[C:4]([CH:11]([CH3:13])[CH3:12])[C:5]=1[C:9]#[N:10]

Komponenten

4

Edukt 2

HCID 784Hydrogen PeroxideHCID 73793209HCID 73793209, Verbindung

Produkt 1

HCID 152801535-Amino-3-isopropylisothiazole-4-carbonitrileAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

While maintaining the temperature below 50°, 86.1 g of 30% hydrogen peroxide was added dropwise to a solution of 128.3 g of 3-amino-2-cyano-4-methyl- 2-pentenethioamide in 600 ml of absolute ethanol. The mixture was stirred at room temperature for 19 hours, filtered and concentrated to about half volume. Water was added to cloud point and the solid allowed to separate. The solid was collected and dried to give 123.0 g of 5-amino-4-cyano-3-isopropylisothiazole, mp 133°-135°.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationconcentrated to about half volume
  3. additionWater was added to cloud point
  4. customto separate
  5. customThe solid was collected
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c228324b2154465c96f2234733245f4b
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04032322

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