Methyl cis(+/-)-2-(acetylamino)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)benzoate → Methyl cis(+/-)-2-(acetylamino)-5-(4-amino-3-methoxypiperidin-1-yl)benzoate

HRID 43806Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 43806
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][C@H:18]([NH:21]C(OCC3C=CC=CC=3)=O)[C@H:17]([O:32][CH3:33])[CH2:16]2)=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2].[H][H]>C(O)C.[C].[Pd]>[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][C@H:18]([NH2:21])[C@H:17]([O:32][CH3:33])[CH2:16]2)=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 86648750Methyl cis(+/-)-2-(acetylamino)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)benzoateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 86648751Methyl cis(+/-)-2-(acetylamino)-5-(4-amino-3-methoxypiperidin-1-yl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Methyl cis(±)-2-(acetylamino)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)benzoate obtained in Example (185c) was dissolved in ethanol (25 mL). A 10% palladium-carbon catalyst (180 mg) was added, and the mixture was stirred in a hydrogen atmosphere overnight. The reaction solution was filtered through celite and then concentrated under reduced pressure to obtain 210 mg of the title compound. The resulting compound was used for the next reaction without purification.

Aufarbeitung

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f3fb8dc7ab42419ca6ac2a4644558142
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536197B2

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