Hydrogen Sulfide → HCID 54512368, Verbindung

HRID 439300Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 439300
[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:17][CH2:18][CH3:19])=[N:14][C:13]=1[CH3:20])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[SH2:21]>N1C=CC=CC=1>[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:17][CH2:18][CH3:19])=[N:14][C:13]=1[CH3:20])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[S:21])[NH2:2]

Komponenten

4

Edukt 2

HCID 402Hydrogen SulfideHCID 22465462HCID 22465462, Verbindung

Produkt 1

HCID 54512368HCID 54512368, VerbindungAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

0.85g of 2-ethylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide (5) was dissolved in 2ml of pyridine and the reaction solution was stirred for 6 hours at 60° C. while introducing hydrogen sulfide gas. After removing the pyridine, the residue was recrystallized from ethylacetate to obtain 0.86g (Yield 91%) of the title compound.

Aufarbeitung

  1. customAfter removing the pyridine
  2. customthe residue was recrystallized from ethylacetate

Quellen und Nachweise

ORD-Eintrag
ord-cf354ad9ab3346b7b0f91ff67c255bb9
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05514643

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