Piperazine → 1-Undecylpiperazine

HRID 439304

Reaktionsgleichung

Reaktionsgleichung von HRID 439304
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClCCl>[CH2:18]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 127441-Bromoundecane

Produkt 1

HCID 129309111-Undecylpiperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Excess piperazine (5 eq) and 1-bromoundecane (1.0 eq) are dissolved in dichloromethane and allowed to react overnight. The mixture is extracted with aqueous sodium bicarbonate and the organic layer dried with sodium sulfate. The mixture is filtered, the solvent removed in vacuo and the residue purified by column chromatography.

Aufarbeitung

  1. customto react overnight
  2. extractionThe mixture is extracted with aqueous sodium bicarbonate
  3. dry with materialthe organic layer dried with sodium sulfate
  4. filtrationThe mixture is filtered
  5. customthe solvent removed in vacuo
  6. customthe residue purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-689265230eda49c3ab363bd8c0763242
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05514651

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