Piperazine → 1-Undecylpiperazine
Reaktionsgleichung
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClCCl>[CH2:18]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Excess piperazine (5 eq) and 1-bromoundecane (1.0 eq) are dissolved in dichloromethane and allowed to react overnight. The mixture is extracted with aqueous sodium bicarbonate and the organic layer dried with sodium sulfate. The mixture is filtered, the solvent removed in vacuo and the residue purified by column chromatography.
Aufarbeitung
- customto react overnight
- extractionThe mixture is extracted with aqueous sodium bicarbonate
- dry with materialthe organic layer dried with sodium sulfate
- filtrationThe mixture is filtered
- customthe solvent removed in vacuo
- customthe residue purified by column chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-689265230eda49c3ab363bd8c0763242
- Quelldatensatz
- uspto-grants-1996_05
- Patentnummer
- US05514651
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