Hydrochloric Acid → Benzoic acid, 2-amino-5-fluoro-3-nitro- (9CI)
Reaktionsgleichung
C([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:11]([F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=O)C.Cl>>[NH2:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:11]([F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]Komponenten
3
Versuchsvorschrift
2-Acetamido-5-fluoro-3-nitrobenzoic acid (200 mg, 0.83 mmol) was added to 3N hydrochloric acid (4.0 mL) and the solution allowed to reflux for 7 hours whereby the solution contained a bright yellow precipitate. The reaction was cooled to room temperature and the precipitate collected and dried to produce 2-amino-5-fluoro-3-nitrobenzoic acid (152 mg, 92%) as a yellow solid.
Aufarbeitung
- temperatureto reflux for 7 hours whereby the solution
- customthe precipitate collected
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-acbae63fd07844028d84db8446c1d9e5
- Quelldatensatz
- uspto-grants-1996_05
- Patentnummer
- US05514676
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