Hydrochloric Acid → 2-Cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

HRID 439561Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 439561
[OH-].[Na+].[C:3]([CH2:5][C:6]([OH:8])=[O:7])#[N:4].[OH:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=1[OH:18])[CH:13]=O.Cl>>[C:3]([C:5](=[CH:13][C:12]1[CH:15]=[CH:16][C:17]([OH:18])=[C:10]([OH:9])[CH:11]=1)[C:6]([OH:8])=[O:7])#[N:4]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 87683,4-DihydroxybenzaldehydeHCID 9740Cyanoacetic acidHCID 14798Sodium Hydroxide

Produkt 1

HCID 20542-Cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

Versuchsvorschrift

To 2N aqueous sodium hydroxide solution (175 ml, 350 mmol) heated at 60° C. were added cyanoacetic acid (7.2 g, 86.7 mmol) and 3, 4-dihydroxybenzaldehyde (12.0 g, 86.9 mmol), and the resulting mixture was stirred for 30 minutes. The reaction mixture was allowed to cool at room temperature and gradually mixed with dilute hydrochloric acid until the reaction mixture became acidic. The product was filtered and dried to give α-cyano-3, 4-dihydroxycinnamic acid (hereinafter referred to as "Compound A" (10.0 g, 56% in yield).

Aufarbeitung

  1. filtrationThe product was filtered
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-83702e63595e4e26b6951b6bf4ae4186
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05514711

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