Methanol → Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methoxybenzoate

HRID 43966Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 43966
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[CH:20][C:21]([O:28][CH3:29])=[C:22]([CH:27]=2)[C:23]([O:25][CH3:26])=[O:24])[CH2:14][C@H:13]1[O:30][CH3:31])=O)C1C=CC=CC=1.CO>[C].[Pd].C(OCC)(=O)C>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[CH:20][C:21]([O:28][CH3:29])=[C:22]([CH:27]=2)[C:23]([O:25][CH3:26])=[O:24])[CH2:14][C@H:13]1[O:30][CH3:31]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 86648847Methyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methoxybenzoate

Produkt 1

HCID 86648848Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methoxybenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The same operation as in Example (40e) was performed using methyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methoxybenzoate obtained in Example (258a) (35 mg, 0.08 mmol), a 10% palladium-carbon catalyst (9 mg), methanol (1.5 mL) and ethyl acetate (1.5 mL), to obtain the title compound. The resulting compound was used for the next reaction without purification.

Quellen und Nachweise

ORD-Eintrag
ord-e5ee5cf50c4f4d93b3d9fe133cbb4f87
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536197B2

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