HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl vinyl ether → 4-Bromo-3-chloro-3,4,4-trifluorobutanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl vinyl ether | HCID 8023 | — |
| Edukt | 1,2-Dibromo-1-chloro-1,2,2-trifluoroethane | HCID 9634 | — |
| Edukt | 4-Bromo-3-chloro-3,4,4-trifluorobutanal | HCID 21836480 | — |
| Edukt | Sodium chlorite hydrogen peroxide | HCID 86632281 | — |
| Edukt | Sodium hydrosulfite sodium bicarbonate | HCID 86749472 | — |
| Produkt | 4-Bromo-3-chloro-3,4,4-trifluorobutanoic acid | HCID 10912127 | — |
Reaktionsschritte
A one pot reaction of 1-chloro-1,2-dibromotrifluoroethane (VI) with ethyl vinyl ether in the presence of sodium hydrosulfite/sodium bicarbonate followed by oxidation of the intermediate, 4-bromo-3-chloro-3,4,4-trifluorobutanal (VII), without isolation, with sodium chlorite/hydrogen peroxide to give 4-bromo-3-chloro-3,4,4-trifluorobutanoic acid (VIII) in overall unexpected yields;
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05514717 |
| Quelldatensatz | uspto-grants-1996_05 |
| ORD ID | ord-87d77a830bdd430eb4084fa8bca22987 |
| Quellennotiz | uspto-grants-1996_05 |