1H-1,2,4-Triazole → 1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

HRID 439676

Reaktionsgleichung

Reaktionsgleichung von HRID 439676
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9](Cl)=[O:10]>C(OCC)(=O)C>[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9]([N:1]1[CH:5]=[N:4][CH:3]=[N:2]1)=[O:10]

Komponenten

4

Edukt 2

HCID 92571H-1,2,4-TriazoleHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

Produkt 1

HCID 218364821-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazoleAusbeute 94,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a clear oil.

Aufarbeitung

  1. stirringThe mixture was stirred for 30 min
  2. filtrationfiltered
  3. customThe residue obtained
  4. customafter evaporation of the solvent
  5. dissolutionwas redissolved in dichloromethane (25 mL)
  6. filtrationfiltered
  7. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-1f418f9a695b4991990cac9f5083dbeb
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05514717

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