Piperazine → 1-Undecylpiperazine

HRID 439704

Reaktionsgleichung

Reaktionsgleichung von HRID 439704
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClCCl>[CH2:18]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 127441-Bromoundecane

Produkt 1

HCID 129309111-Undecylpiperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Excess piperazine (5 eq) and 1-bromoundecane (1.0 eq) are dissolved in dichloromethane and allowed to react overnight. The mixture is extracted with aqueous sodium bicarbonate and the organic layer dried with sodium sulfate. The mixture is filtered, the solvent removed in vacuo and the residue purified by column chromatography.

Aufarbeitung

  1. customto react overnight
  2. extractionThe mixture is extracted with aqueous sodium bicarbonate
  3. dry with materialthe organic layer dried with sodium sulfate
  4. filtrationThe mixture is filtered
  5. customthe solvent removed in vacuo
  6. customthe residue purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-26b78d94fcec4e31a6a456affacbfbdb
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05516756

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