Hydrochloric Acid → HCID 21473349, Verbindung

HRID 440247

Reaktionsgleichung

Reaktionsgleichung von HRID 440247
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:20])[CH2:9]1)=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[OH:20][CH:10]1[CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][NH:8][CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 214733471-t-Butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine

Produkt 1

HCID 21473349HCID 21473349, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In 100 ml of methanol was dissolved 2.4 g (0.0086 mole) of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine obtained as described above, and 30 ml of 6N hydrochloric acid was added thereto. After the mixture was refluxed by heating for 2.5 hours, the solvent was removed under reduced pressure. The resulting residue was washed with ethanol and ether to obtain 1.52 g of 3-hydroxy-4-phenylaminopyrrolidine hydrochloride as light brown powder.

Aufarbeitung

  1. customobtained
  2. additionwas added
  3. temperatureAfter the mixture was refluxed
  4. temperatureby heating for 2.5 hours
  5. customthe solvent was removed under reduced pressure
  6. washThe resulting residue was washed with ethanol and ether

Quellen und Nachweise

ORD-Eintrag
ord-a89ab264fdd34f32a615651710c675eb
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05519016

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