1-(2-Hydroxyethyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-(2-Hydroxyethyl)-6,8-difluoro-7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

HRID 440269

Reaktionsgleichung

Reaktionsgleichung von HRID 440269
[OH:1][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][C:10]([F:16])=[C:11](F)[C:12]=2[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]1.[N:21]1[CH:22]=[CH:23][N:24]2[CH2:29][CH2:28][NH:27][CH2:26][C:25]=12>>[OH:1][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][C:10]([F:16])=[C:11]([N:27]3[CH2:28][CH2:29][N:24]4[CH:23]=[CH:22][N:21]=[C:25]4[CH2:26]3)[C:12]=2[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]1

Komponenten

3

Edukt 2

HCID 127709171-(2-Hydroxyethyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 132470465,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine

Produkt 1

HCID 154114811-(2-Hydroxyethyl)-6,8-difluoro-7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Versuchsvorschrift

Using 1-(2-hydroxyethyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine, the same procedure as in Production Example 1 was followed to yield the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-e9106df6c62a44f4a03e829cf9e6b4b4
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05519024

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