Potassium Carbonate → 2-Amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine

HRID 440912

Reaktionsgleichung

Reaktionsgleichung von HRID 440912
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5](Br)=[CH:4][N:3]=1.[OH:11][CH:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[C:20](B(O)O)[C:15]=2[O:14][C:13]1([CH3:25])[CH3:24].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:20]2[C:15]3[O:14][C:13]([CH3:24])([CH3:25])[CH:12]([OH:11])[C:16]=3[CH:17]=[CH:18][CH:19]=2)=[CH:4][N:3]=1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 110526113-Amino-6-bromopyrazine-2-carbonitrileHCID 190407762,3-Dihydro-3-hydroxy2,2-dimethylbenzofuran-7-ylboronic acid

Produkt 1

HCID 190407832-Amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

This compound is prepared in a manner analogous to that of Step A of Example 4, using 1.6 grams (0.008 mole) of 2-amino-3-cyano-5-bromopyrazine, 2.5 grams (0.012 mole) of 2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-ylboronic acid, 4.3 grams (0.031 mole) of potassium carbonate and 0.3 gram of tetrakis(triphenylphosphine)palladium(0) in 150 mL of toluene, yielding 2-amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine.

Aufarbeitung

  1. customThis compound is prepared in a manner analogous to that of Step A of Example 4

Quellen und Nachweise

ORD-Eintrag
ord-04143c6ff88b40658fbfa22022c351fe
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05521190

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