Phenylsulphonyl isocyanate → HCID 22405567, Verbindung

HRID 441207

Reaktionsgleichung

Reaktionsgleichung von HRID 441207
[NH2:1][C:2]1[C:3](=[O:28])[N:4]([CH2:14][C:15]([NH:17][CH:18]([CH:25]([CH3:27])[CH3:26])[C:19](=[O:24])[C:20]([F:23])([F:22])[F:21])=[O:16])[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[C:29]1([S:35]([N:38]=[C:39]=[O:40])(=[O:37])=[O:36])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>ClCCl>[O:28]=[C:3]1[C:2]([NH:1][C:39]([NH:38][S:35]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)(=[O:37])=[O:36])=[O:40])=[CH:7][CH:6]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:4]1[CH2:14][C:15]([NH:17][CH:18]([CH:25]([CH3:26])[CH3:27])[C:19](=[O:24])[C:20]([F:22])([F:23])[F:21])=[O:16]

Komponenten

4

Edukt 2

HCID 76096Phenylsulphonyl isocyanateHCID 102500732-(3-Amino-2-oxo-6-phenyl-2H-pyridin-1-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

Produkt 1

HCID 22405567HCID 22405567, VerbindungAusbeute 96,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide (0.5 g) in dichloromethane (40 mL) was added benzenesulfonyl isocyanate (0.23 g), and the resulting solution was allowed to stir for 1 h. The solvent was evaporated and the product was purified by chromatography to provide the title compound (0.7 g); chromatography solvent: methanol:dichloromethane (5:95); TLC: Rf =0.6, methanol:dichloromethane (10:90); MS: m/z=579(M+1), 577(M-1) by FAB.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe product was purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-0b587c787bfe494e82e884f6c858bc05
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05521179

Verknüpfte Notizen

Wird geladen…