Diketene → m-Propionamido-acetylacetanilide

HRID 441274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 441274
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[NH:11][C:12](=[O:15])[CH2:13][CH3:14]>C1C=CC=CC=1>[C:12]([NH:11][C:10]1[CH:9]=[C:8]([CH:18]=[CH:17][CH:16]=1)[NH:7][C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1])(=[O:15])[CH2:13][CH3:14]

Komponenten

4

Edukt 2

HCID 12661DiketeneHCID 89953N-(3-Aminophenyl)propanamide

Produkt 1

HCID 21419827m-Propionamido-acetylacetanilideAusbeute 95,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

42 g of diketene were added to a solution of 82.1 g of m-aminopropionanilide in 400 ml of benzene and the mixture was stirred for 41/2 hours and then was vacuum filtered. The recovered precipitate was washed with benzene, then isopropyl ether and dried to obtain 118 g of m-propionamido-acetylacetanilide melting at 70° C. which was used as is for the next step.

Aufarbeitung

  1. filtrationfiltered
  2. washThe recovered precipitate was washed with benzene
  3. dry with materialisopropyl ether and dried

Quellen und Nachweise

ORD-Eintrag
ord-549f179fa804483996fb523fc0bbcdac
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04039316

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