Piperidine → Ethyl 2-methyl-4-piperidinobutyrate

HRID 441879

Reaktionsgleichung

Reaktionsgleichung von HRID 441879
Br[CH2:2][CH2:3][CH:4]([CH3:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C1C=CC=CC=1>[CH3:10][CH:4]([CH2:3][CH2:2][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 12780980Ethyl 4-bromo-2-methylbutanoate

Produkt 1

HCID 20361120Ethyl 2-methyl-4-piperidinobutyrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

10.5 g. (0.05 mole) of ethyl γ-bromo-α-methylbutyrate was combined with 17.0 g. (0.20 mole) of piperidine and 100 ml. of benzene and stirred for 16 hours at room temperature and heated at 60° C. for 4 hours. The reaction mixture was cooled and the colorless solid which appeared was removed by filtration. The mother liquor was concentrated to give ethyl α-methyl-γ-piperidinobutyrate as a mobile yellow liquid which distilled (b.p. 78° C. at 0.25 mm.) as 6.7 g. (63%) of colorless liquid. The nuclear magnetic resonance and infrared spectra were consistent with the desired compound.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customthe colorless solid which appeared was removed by filtration
  3. concentrationThe mother liquor was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-5285d10f4538403f9ea38ebefec88d98
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04042694

Verknüpfte Notizen

Wird geladen…