Methanol → HCID 178494290, Verbindung
Reaktionsgleichung
[CH:1]([N:4]1[C:8](Cl)=[N:7][C:6]([OH:10])=[N:5]1)([CH3:3])[CH3:2].[Na].[CH3:12][OH:13]>>[CH:1]([N:4]1[C:8]([O:13][CH3:12])=[N:7][C:6]([OH:10])=[N:5]1)([CH3:3])[CH3:2]Komponenten
4
Reaktionsbedingungen
- Temperatur
- -70 °C
Versuchsvorschrift
An amount of 166 g of 1-isopropyl-3-hydroxy-5-chloro-1,2,4-triazole is added to a solution of 115 g of sodium in 1000 ml of methanol; the mixture is then refluxed for 15 hours. After separation of filtration of the precipitated sodium chloride, and concentration of the filtrate in vacuo, the residue is taken up in dilute acetic acid and extracted twice with ether. The ether is evaporated off, and the partially crystalline residue dissolved in a little methanol. On cooling of the solution to -70° C, the product crystallises out. There is thus obtained 43.5 g of 1-isopropyl-3-hydroxy-5-methoxy-1,2,4-triazole in the form of white crystals, M.P. 102° -103° C.