Phosgene → 5-Trifluoromethylbenzothiazol-2-yl isocyanate

HRID 442378Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 442378
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=2[N:10]=1>C(OCC)(=O)C>[F:18][C:15]([F:16])([F:17])[C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([N:5]=[C:1]=[O:2])=[N:10][C:9]=2[CH:11]=1

Komponenten

4

Edukt 2

HCID 6371PhosgeneHCID 70186255-(Trifluoromethyl)-1,3-benzothiazol-2-amine

Produkt 1

HCID 544616495-Trifluoromethylbenzothiazol-2-yl isocyanate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A saturated solution of phosgene in ethyl acetate (200 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Amino-5-trifluoromethylbenzothiazole (0.1 mole) is added with stirring. After the addition is completed, the reaction mixture is heated at reflux for a period of about one hour. After this time the mixture is cooled, and the solid product formed is recovered by filtration. The solid is then dried to yield the desired product 5-trifluoromethylbenzothiazol-2-yl isocyanate dimer.

Aufarbeitung

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. additionAfter the addition
  4. temperaturethe reaction mixture is heated
  5. temperatureat reflux for a period of about one hour
  6. temperatureAfter this time the mixture is cooled
  7. customthe solid product formed
  8. filtrationis recovered by filtration
  9. customThe solid is then dried

Quellen und Nachweise

ORD-Eintrag
ord-136eb08651784e47a49c1c19eede58d9
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04045446

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