Imidazole → 1-[4-(4-Chlorophenyl)butan-4-onyl]imidazole

HRID 442509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 442509
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[CH:6]1[C:11]([C:12]([CH2:14][CH2:15][CH2:16]Cl)=[O:13])=[CH:10][CH:9]=[C:8]([Cl:18])[CH:7]=1>CN(C)C=O>[Cl:18][C:8]1[CH:7]=[CH:6][C:11]([C:12](=[O:13])[CH2:14][CH2:15][CH2:16][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 795ImidazoleHCID 27237814,4'-Dichlorobutyrophenone

Produkt 1

HCID 190783351-[4-(4-Chlorophenyl)butan-4-onyl]imidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a 0° C. slurry of 10.5 g. of imidazole in 15 ml. dry dimethylformamide was added 6.5 g. of γ,p-dichlorobutyrophenone and the mixture was stirred overnight at room temperature then one day at 60° C. The above solution was poured into 400 ml. of water and extracted three times with ethyl acetate. The combined extracts were washed with water, dried over magnesium sulfate and the solvent evaporated to afford 1-[4-(4-chlorophenyl)butan-4-onyl]imidazole, which was used in the next step. This material may be further purified, if necessary, through the nitrate salt.

Aufarbeitung

  1. customTo a 0° C.
  2. customone day
  3. customat 60° C
  4. additionThe above solution was poured into 400 ml
  5. extractionof water and extracted three times with ethyl acetate
  6. washThe combined extracts were washed with water
  7. dry with materialdried over magnesium sulfate
  8. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8638fe06652943ee8f370931966af829
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04045568

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