Hydrochloric Acid → 4'-Nonanoyloxybiphenyl-4-carboxylic acid

HRID 442594

Reaktionsgleichung

Reaktionsgleichung von HRID 442594
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:17](Cl)(=[O:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].CN(C1C=CC=CN=1)C.Cl>ClCCl.C(N(CC)CC)C>[C:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1)(=[O:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 218852-DimethylaminopyridineHCID 69819Nonanoyl chlorideHCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

Produkt 1

HCID 136684514'-Nonanoyloxybiphenyl-4-carboxylic acidAusbeute 86,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

4'-Hydroxybiphenyl-4-carboxylic acid (3.5 g) and triethylamine (2.4 g) were dissolved in dichloromethane (30 ml). Nonanoyl chloride (4.3 g) and dimethylaminopyridine (0.2 g) were added to the solution, and the mixture was stirred at room temperature for about 20 hours. Dilute hydrochloric acid was added thereto, and the organic layer was separated in a separating funnel. The solvent was removed by evaportaion, and the residue was dried after washing with n-hexane to give the titled compound (5 g).

Aufarbeitung

  1. customthe organic layer was separated in a separating funnel
  2. customThe solvent was removed by evaportaion
  3. customthe residue was dried
  4. washafter washing with n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-0fbb1e06db2441929e7b81c2113f4d94
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891359

Verknüpfte Notizen

Wird geladen…