Dimethylformamide → Octyl 4'-hydroxy-4-biphenylcarboxylate

HRID 442597

Reaktionsgleichung

Reaktionsgleichung von HRID 442597
FC(F)(F)[CH:3]([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].CN(C)[CH:15]=[O:16].[CH2:18](N(CC)CC)[CH3:19].[CH:25]1[C:34]2[C:29](=[CH:30][C:31]([C:35](Cl)=[O:36])=[CH:32][CH:33]=2)C=C[C:26]=1[C:38](Cl)=O.[CH2:41](Cl)Cl>>[CH2:3]([O:10][C:35]([C:31]1[CH:32]=[CH:33][C:34]([C:25]2[CH:26]=[CH:38][C:15]([OH:16])=[CH:19][CH:18]=2)=[CH:29][CH:30]=1)=[O:36])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:41]

Komponenten

6

Edukt 5

HCID 6228DimethylformamideHCID 6344Dichloromethane2×HCID 8471TriethylamineHCID 978042-Octanol, 1,1,1-trifluoro-HCID 34855962,6-Naphthalenedicarbonyl dichloride

Produkt 1

HCID 14692993Octyl 4'-hydroxy-4-biphenylcarboxylate

Versuchsvorschrift

Optically active 1,1,1-trifluoro-2-octanol (0.3 g), dimethylformamide (0.2 g) and triethylamine (0.18 g) were dissolved in methylene chloride (20 ml). To this solution was added in small portions a solution of 2,6-naphthalenedicarboxylic acid dichloride (0.8 g) obtained in the step 2) of Example 7 in methylene chloride (50 ml) under ice-cooling, and the mixture was stirred for about 20 hours. Next, 4-n-octyloxycarbonyl-4'-hydroxybiphenyl (0.55 g) obtained in the step 1) was dissolved in methylene chloride (30 ml) and added in small portions to the reaction mixture. The resulting mixture was stirred for about 20 hours.

Aufarbeitung

  1. temperaturecooling

Quellen und Nachweise

ORD-Eintrag
ord-401bdc46047c4f3aa69c17a8d3cd0a1a
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891359

Verknüpfte Notizen

Wird geladen…