Monoethyl malonate → Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

HRID 442797

Reaktionsgleichung

Reaktionsgleichung von HRID 442797
[CH3:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[Li][Li].[C:14]([O:20][CH2:21][CH3:22])(=[O:19])[CH2:15]C(O)=O>>[CH3:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([CH2:15][C:14]([O:20][CH2:21][CH3:22])=[O:19])=[O:5]

Komponenten

4

Edukt 3

HCID 70615Monoethyl malonateHCID 139759Lithium, mol. (Li2)HCID 128464834-Bromo-2-methylbenzoyl chloride

Produkt 1

HCID 53404613Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

Versuchsvorschrift

2-Methyl-4-bromobenzoyl chloride (29.1 g, 0.13 mol) was treated with the dilithium salt of ethyl hydrogen malonate (28.0 g, 0.21 mol) and the product was isolated by the procedure described in Example 1 (ii). The crude product was purified on flash silica, eluting with dichloromethane-hexane (1:1 then 3:2) to give ethyl 2-methyl-4-bromobenzoylacetate as an oil.

Aufarbeitung

  1. customthe product was isolated by the procedure
  2. customThe crude product was purified on flash silica
  3. washeluting with dichloromethane-hexane (1:1

Quellen und Nachweise

ORD-Eintrag
ord-ddc09ecaf6e64ae8b211449d5c77514a
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891899

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