Hydrochloric Acid → 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

HRID 443216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 443216
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][C:17]1[CH:16]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:20]=[CH:19][CH:18]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21193300N-t-Butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine

Produkt 1

HCID 211931674-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of N-t-butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine (0.546 mg, 1.87 mmol) in EtOAc (30 ml) at 0° C. was bubbled gasseous HCl until saturated. After 10 min the solvent was evaporated in vacuo to afford the title compound of sufficient purity to be used in the next step.

Aufarbeitung

  1. customAfter 10 min the solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8446683b209e4700a6482f9df30aa441
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891889

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