Hydrochloric Acid → 1-(2-naphthylmethyl)-1H-imidazol-5-ylacetic acid hydrochloride

HRID 443232Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 443232
C[O:2][C:3](=[O:21])[CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=2)[CH:8]=[N:7][CH:6]=1.[ClH:22]>>[ClH:22].[CH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:19]=[CH:20][C:11]=1[CH2:10][N:9]1[C:5]([CH2:4][C:3]([OH:21])=[O:2])=[CH:6][N:7]=[CH:8]1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 538068662-[1-(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetic acid methyl ester

Produkt 1

HCID 702062051-(2-naphthylmethyl)-1H-imidazol-5-ylacetic acid hydrochloride

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

2-[1-(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetic acid methyl ester (0.92 g, 3.28 mmol ) was dissolved in 2.5N hydrochloric acid (50 ml ) and heated to 55° C. for 3 hr. After this time, the solution was concentrated to dryness in vacuo to give the title compound as a white solid.

Aufarbeitung

  1. concentrationAfter this time, the solution was concentrated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-88c59fffcc834ac3b37a55225513e4e1
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891889

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