2-(Trifluoromethoxy)benzyl bromide → 4-{5-[4-Methoxymethyl-4-(2-trifluoromethoxybenzyl)-piperidine-1-ylmethyl]-2-methylimidazol-1-ylmethyl}benzonitrile hydrochloride salt

HRID 443262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 443262
F[C:2](F)(F)OC1C=CC=CC=1CBr.C(O[N:19]1[CH2:24][CH2:23][C:22]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[O:34][C:35]([F:38])([F:37])[F:36])([CH2:25][OH:26])[CH2:21][C:20]1=C=O)(C)(C)C.Cl.[C:42]([C:44]1[CH:58]=[CH:57][C:47]([CH2:48][N:49]2[C:53]([CH2:54][Cl:55])=[CH:52][N:51]=[C:50]2[CH3:56])=[CH:46][CH:45]=1)#[N:43]>>[ClH:55].[CH3:2][O:26][CH2:25][C:22]1([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[O:34][C:35]([F:38])([F:36])[F:37])[CH2:21][CH2:20][N:19]([CH2:54][C:53]2[N:49]([CH2:48][C:47]3[CH:57]=[CH:58][C:44]([C:42]#[N:43])=[CH:45][CH:46]=3)[C:50]([CH3:56])=[N:51][CH:52]=2)[CH2:24][CH2:23]1

Komponenten

4

Edukt 3

HCID 27772542-(Trifluoromethoxy)benzyl bromideHCID 211933481-(4-Cyanobenzyl)-5-chloromethyl-2-methylimidazole hydrochloride saltHCID 86754054N-tert-butoxy-carbonyl-4-(2-trifluoromethoxybenzyl)-4-hydroxymethylpiperidine

Produkt 1

HCID 211931664-{5-[4-Methoxymethyl-4-(2-trifluoromethoxybenzyl)-piperidine-1-ylmethyl]-2-methylimidazol-1-ylmethyl}benzonitrile hydrochloride salt

Versuchsvorschrift

The title compound was prepared using the protocol described in Example 30, Step A-C using 2-(trifluoromethoxy)benzyl bromide in Step B, and in Example 52, Step B-E substituting N-tert-butoxycarbonyl-4-(3-methylbenzyl)-4-hydroxymethylpiperidine with N-tert-butoxy-carbonyl-4-(2-trifluoromethoxybenzyl)-4-hydroxymethylpiperidine in Step B, and substituting 1-(4-cyanobenzyl)-5-chloromethyl-imidazole hydrochloride salt with 1-(4-cyanobenzyl)-5-chloromethyl-2-methylimidazole hydrochloride salt in Step E.

Quellen und Nachweise

ORD-Eintrag
ord-32f70047ac954a21a0e556edff8b406c
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891889

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