HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzaldehyde → 2-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzaldehyde | HCID 240 | — |
| Edukt | 2-Amino-4,5-dimethyl-thiophene-3-carbonitrile | HCID 290236 | — |
| Edukt | Cyano-borohydride | HCID 498716 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Lösungsmittel | 1,1-Dichloroethane | HCID 6365 | — |
| Produkt | 2-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile | HCID 319451 | — |
Reaktionsschritte
To a solution of 2-amino-4,5-dimethylthiophene-3-carbonitrile (151 mg, 1.0 mmol) and benzaldehyde (106 mg, 1 mmol) in 15 mL of 4% acetic acid in dichloroethane was added silica supported cyanoborohydride (2.0 g. 2.0 mmol). The reaction was placed in a microwave reactor for 5 minutes at 135° C. Silica supported cyanoborohydride was removed by filtration, and the product was purified by prep HPLC using acetonitrile/water as solvent. MS 243 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08541421B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-77eaccefdd3b4e7e9282a9c89df827f7 |
| Quellennotiz | uspto-grants-2013_09 |