5-(Methylsulfanyl)-2-nitrobenzoic acid → 2-Amino-5-(methylsulfanyl)benzoic acid

HRID 443826Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 443826
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N+:12]([O-])=O)=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9].[H][H]>[Ni].CO>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:12])=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9]

Komponenten

5

Edukt 2

HCID 89345765-(Methylsulfanyl)-2-nitrobenzoic acidHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 127132522-Amino-5-(methylsulfanyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 5-methylthio-2-nitrobenzoic acid (25.4 g; 0.119 mole), methanol (200 ml) and Raney nickel (2 g) is shaken in an atmosphere of hydrogen at 50 lb pressure when theoretical amount of hydrogen is absorbed. The catalyst is filtered off and the filtrate evaporated to dryness. The residue is recrystallized from etheriso-Pr2O. Yield 7.6 g; mp 145°-150°.

Aufarbeitung

  1. customis absorbed
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate evaporated to dryness
  4. customThe residue is recrystallized from etheriso-Pr2O

Quellen und Nachweise

ORD-Eintrag
ord-b25cfef8cded444f874966915cfbe930
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04261996

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