(3-Mercaptopropyl)ammonium chloride → HCID 178479415, Verbindung

HRID 444002

Reaktionsgleichung

Reaktionsgleichung von HRID 444002
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][SH:6].[O-]CC.[Na+].Cl.[NH:12]([C:16]1[S:17][CH:18]=[C:19]([CH2:21][Cl:22])[N:20]=1)[C:13]([NH2:15])=[NH:14]>C(O)C>[ClH:22].[NH:12]([C:16]1[S:17][CH:18]=[C:19]([CH2:21][S:6][CH2:5][CH2:4][CH2:3][NH2:2])[N:20]=1)[C:13]([NH2:15])=[NH:14]

Komponenten

5

Edukt 3

HCID 197870(3-Mercaptopropyl)ammonium chlorideHCID 2723922Sodium ethoxideHCID 178479412HCID 178479412, Verbindung

Produkt 1

HCID 178479415HCID 178479415, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

3-Aminopropanethiol hydrochloride (2.54 g.) in ethanol (20 ml.) was added to a solution of sodium ethoxide (1 g. Na in 25 ml. ethanol) at 0° C. under a nitrogen atmosphere. The suspension was stirred at 0° C. for 2 hours and a solution of 2-guanidino-4-chloromethylthiazole hydrochloride (2.27 g.) in ethanol (25 ml.) was then added. The suspension was allowed to reach room temperature and stirred for 16 hours. Filtration of the suspension and acidification of the filtrate with concentrated hydrochloric acid gave a precipitate of 2-guanidino-4-[(3-aminopropyl)thiomethyl]thiazole hydrochloride, m.p. >350° C.

Aufarbeitung

  1. customto reach room temperature
  2. stirringstirred for 16 hours
  3. filtrationFiltration of the suspension and acidification of the filtrate with concentrated hydrochloric acid

Quellen und Nachweise

ORD-Eintrag
ord-2eaa7a1c3b8a4f88928dbeab9b9a7f6d
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04262126

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