Dimethylformamide → 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran

HRID 444082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 444082
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7]([CH3:11])([CH3:10])[C:6]=2[CH:12]=1.[CH3:13][N:14](C)C=O>>[C:13]([C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7]([CH3:11])([CH3:10])[C:6]=2[CH:12]=1)#[N:14]

Komponenten

3

Edukt 2

HCID 6228DimethylformamideHCID 53235955-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran

Produkt 1

HCID 205361905-Cyano-2,3-dihydro-3,3-dimethylbenzofuran

Versuchsvorschrift

5-Bromo-2,3-dihydro-3,3-dimethylbenzofuran (15 g, 0.066 mole) was heated under reflux with cuprous cyanide (7.2 g. 0.08 mole) in dimethyl formamide (15 ml) as in Example 2. Work up yielded, after recrystallisation from petroleum ether (bp 60°-80° C.) with charcoaling, 5.7 g of product, mp 72°-75° C.

Aufarbeitung

  1. customWork up yielded
  2. customafter recrystallisation from petroleum ether (bp 60°-80° C.) with charcoaling, 5.7 g of product, mp 72°-75° C.

Quellen und Nachweise

ORD-Eintrag
ord-ad44c049a2b543cba4bb3fed2272fe36
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04263037

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