3-Hydroxypropionic acid → beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylate

HRID 444168

Reaktionsgleichung

Reaktionsgleichung von HRID 444168
Cl[C:2]([C:4]1[CH:19]=[CH:18][C:7]2[C:8](=[O:17])[NH:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[S:12][C:6]=2[CH:5]=1)=[O:3].[Na].[OH:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25]>O1CCCC1>[O:17]=[C:8]1[C:7]2[CH:18]=[CH:19][C:4]([C:2]([O:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[O:3])=[CH:5][C:6]=2[S:12][C:11]2[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=2[NH:9]1

Komponenten

5

Edukt 3

HCID 681523-Hydroxypropionic acidHCID 5360545SodiumHCID 234644803-Chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin

Produkt 1

HCID 23464478beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Dissolve 1.0 gm. of 3-chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepine in 20 cc. of tetrahydrofuran and add 1.0 gm. of the sodium salt of β-hydroxypropionic acid. Stir the mixture at room temperature for 18 hours. Filter and evaporate the filtrate to dryness. Recrystallize the solid residue from ethanol to obtain the title product.

Aufarbeitung

  1. dissolutionDissolve 1.0 gm
  2. filtrationFilter
  3. customevaporate the filtrate to dryness
  4. customRecrystallize the solid residue from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-b6769a818fde43e9850d0873255c633c
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04263207

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