Dimethylamine → 2-(2-(2-(Dimethylamino)ethoxy)ethoxy)ethanol
Reaktionsgleichung
Cl[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([CH3:13])[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10]Komponenten
3
Versuchsvorschrift
Commercial Cl(CH2CH2O)3H (abb. ClE3H) (2.0 mole) and dimethylamine (20.0 mole) were mixed in a flask (3.0 l) fitted with a condenser and stirred (RT) for 30 hours. TLC (Si-gel) examination showed the complete consumption of the ClE3H. Excess dimethylamine was removed by two consecutive evaporations under reduced pressure. The residual material was reconstituted in CHCl3, dried (MgSO4), filtered and evaporated to dryness to produce the product, 8-dimethylamino-3,6-dioxaoctanol.
Aufarbeitung
- customfitted with a condenser
- customthe complete consumption of the ClE3H
- customExcess dimethylamine was removed by two consecutive evaporations under reduced pressure
- dry with materialdried (MgSO4)
- filtrationfiltered
- customevaporated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-640529c8258d4e74a8dd8c70eedc4121
- Quelldatensatz
- uspto-grants-1981_04
- Patentnummer
- US04263281
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