Hydrochloric Acid → 9-Chloro-9-(4-diethylaminophenyl)-10-phenylacridan

HRID 444297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 444297
[CH2:1]([N:3]([CH2:32][CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2(OC)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:6][CH:5]=1)[CH3:2].[ClH:34]>O1CCCC1>[CH2:1]([N:3]([CH2:32][CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2([Cl:34])[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:6][CH:5]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 13014081HCID 13014081, Verbindung

Produkt 1

HCID 934619-Chloro-9-(4-diethylaminophenyl)-10-phenylacridanAusbeute 95,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

9(p-Diethylaminophenyl)-9-methoxy-10-phenylacridan (12.0 g, 0.0276 mole) is slurried in 150 ml of tetrahydrofuran while anhydrous hydrogen chloride is bubbled in with cooling. The hydrogen chloride is bubbled in until the slurry reaches a pH of 1.0 and a bright yellow color is obtained. The product is collected on a Buchner funnel, washed twice with 10 ml portions of tetrahydrofuran and dried at 50° C. to give 11.6 g (95.8% yield) of 9(p-diethylaminophenyl)-9-chloro-10-phenylacridan.

Aufarbeitung

  1. customis bubbled in
  2. temperaturewith cooling
  3. customThe hydrogen chloride is bubbled in until the slurry
  4. customa bright yellow color is obtained
  5. customThe product is collected on a Buchner funnel
  6. washwashed twice with 10 ml portions of tetrahydrofuran
  7. customdried at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-41c6b5d04df84e44ab94536377e050ce
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04263398

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