Acetone → HCID 178479714, Verbindung

HRID 444385

Reaktionsgleichung

Reaktionsgleichung von HRID 444385
[N:1]1([CH2:6][CH2:7][S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:16]1([N:22]=[C:23]([Cl:30])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CC(C)=[O:33]>>[ClH:30].[N:1]1([CH2:6][CH2:7][S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[C:23](=[N:22][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[OH:33])[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 3

HCID 180AcetoneHCID 264587N-Phenylbenzimidoyl chlorideHCID 234636742-[beta-(1-Pyrrolidinyl)ethylthio]phenol

Produkt 1

HCID 178479714HCID 178479714, VerbindungAusbeute 55 %

Versuchsvorschrift

A solution of 5.5 gms (0.025 mole) of 2-[β-(1-pyrrolidinyl)ethylthio]phenol and 5.3 gms (0.025 mole) of N-phenylbenzimidoyl chloride in 50 ml acetone was stirred at room temperature for a period of two hours. The desired product crystallized out. It was filtered, washed with acetone and dried at room temperature. Recrystallization from isopropanol yielded 6.0 gms (55%) of product, M.P. 167°-9° C.

Aufarbeitung

  1. customThe desired product crystallized out
  2. filtrationIt was filtered
  3. washwashed with acetone
  4. customdried at room temperature
  5. customRecrystallization from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-ab2aae96cb804d669c17c205bc8864e3
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04264505

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