(4-Chloro-2-methylphenyl)boronic acid → 3-Amino-6-(4-chloro-2-methyl-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid

HRID 444938

Reaktionsgleichung

Reaktionsgleichung von HRID 444938
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[C:7](Br)[N:6]=1)=[O:4].[Cl:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[C:20]([CH3:27])[CH:19]=1>>[NH2:11][C:10]1[C:5]([C:3]([OH:2])=[O:4])=[N:6][C:7]([C:21]2[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][C:20]=2[CH3:27])=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=1

Komponenten

3

Edukt 2

HCID 5017600(4-Chloro-2-methylphenyl)boronic acidHCID 58964428Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate2×

Produkt 1

HCID 681695403-Amino-6-(4-chloro-2-methyl-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid

Versuchsvorschrift

This compound was prepared from 3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A4) and 4-chloro-2-methylphenylboronic acid analogously to Intermediate H; LC-MS Rt=1.53 mins, [M+H]+ 331 (Method 2 min LC_v002).

Aufarbeitung

  1. customLC-MS Rt=1.53 mins, [M+H]+ 331 (Method 2 min LC_v002)

Quellen und Nachweise

ORD-Eintrag
ord-6e675906c96b4adb9caa95d8fc401b9b
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476269B2

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