(4-Isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone → (2-Amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone

HRID 445152Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 445152
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[N+:20]([O-])=O)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>CO.[Ni]>[NH2:20][C:13]1[CH:14]=[CH:15][C:16]([O:18][CH3:19])=[CH:17][C:12]=1[C:10]([C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1)=[O:11]

Komponenten

4

Edukt 1

HCID 45140002(4-Isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone

Produkt 1

HCID 45139626(2-Amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 5.6 g (18.7 mmol) (4-isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone in 100 ml methanol is hydrogenated in the presence of 2 g Raney nickel at 5 bar for 5 h. The reaction mixture is filtered and the filtrate is evaporated. The residue is dissolved in ether and the product is precipitated by the addition of gaseous hydrochloric acid as its hydrochloride.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated
  3. dissolutionThe residue is dissolved in ether
  4. customthe product is precipitated by the addition of gaseous hydrochloric acid as its hydrochloride

Quellen und Nachweise

ORD-Eintrag
ord-d122323607074917822bc541d808a9b9
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476286B2

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