Methanol → HCID 59619635, Verbindung

HRID 445653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 445653
[Na].Cl[C:3]1[C:8]([O:9][CH:10]([CH3:12])[CH3:11])=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:13][OH:14]>>[CH:10]([O:9][C:8]1[C:3]([O:14][CH3:13])=[N:4][CH:5]=[CH:6][CH:7]=1)([CH3:12])[CH3:11]

Komponenten

4

Edukt 3

HCID 887Methanol2×HCID 5360545SodiumHCID 336790892-Chloro-3-[(propan-2-yl)oxy]pyridine

Produkt 1

HCID 59619635HCID 59619635, Verbindung

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

To a solution of methanolate obtained by dissolving sodium (534 mg, 23.25 mmol) in MeOH (8 ml) was added a solution of 2-chloro-3-isopropoxy-pyridine (Stage 93.1.4, 1.14 g, 6.64 mmol) in MeOH (2 ml). The reaction mixture was heated at 150° C. by microwave irradiation for 25 min then concentrated and quenched with EtOAc and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give the title compound as an oil (HPLC: tR 2.66 min (Method A); M+H=264 MS-ES)

Aufarbeitung

  1. concentrationthen concentrated
  2. customquenched with EtOAc and brine
  3. dry with materialThe organic layer was dried over Na2SO4
  4. filtrationfiltered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-53667973c7e14d1eab3e41913cde97bb
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476294B2

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