Piperidine → HCID 86675361, Verbindung

HRID 446059

Reaktionsgleichung

Reaktionsgleichung von HRID 446059
[I:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([CH:13]=O)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:15]([O:17][C:18](=[O:27])[CH2:19][N:20]1[C:24](=[O:25])[CH2:23][NH:22][C:21]1=[S:26])[CH3:16].N1CCCCC1>ClCCl>[CH2:15]([O:17][C:18](=[O:27])[CH2:19][N:20]1[C:24](=[O:25])/[C:23](=[CH:13]/[C:11]2[O:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([I:1])[CH:3]=3)=[CH:9][CH:10]=2)/[NH:22][C:21]1=[S:26])[CH3:16]

Komponenten

5

Edukt 3

HCID 8082PiperidineHCID 43155822HCID 43155822, VerbindungHCID 43995697Ethyl-2-(5-oxo-2-thioxoimidazolidin-1-yl)acetate

Produkt 1

HCID 86675361HCID 86675361, VerbindungAusbeute 43,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

5-(3-Iodophenyl)furan-2-carbaldehyde (30 mg, 0.1 mmol) synthesized by the same method as in Example 1 and ethyl-2-(5-oxo-2-thioxoimidazolidin-1-yl)acetate (20 mg, 0.1 mmol) were dissolved in dichloromethane (7 mL), piperidine (20 μL) was added thereto, and the mixture was stirred at room temperature (25° C.) overnight. After the reaction was completed the solvent was removed by evaporation under reduced pressure, and the residue was subjected to silica gel column chromatography using ethyl acetate/hexane (3/7 (volume ratio)) as an eluent, to give compound 2 in a yield of 21 mg (yield 43.6%).

Aufarbeitung

  1. customwas removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8b5708c1b379492382885c12243bcee2
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476449B2

Verknüpfte Notizen

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