Triethylamine → HCID 58168471, Verbindung

HRID 446428Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 446428
CN([C:4]([O:8]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH2:25]([C:27]1[S:28][CH:29]=[C:30]([C:32]([N:34]2[CH2:39][C:38]3([CH2:44][CH2:43][N:42]([CH2:45][CH2:46][C:47]4[CH:60]=[CH:59][C:50]([CH2:51][CH2:52][O:53][CH2:54][CH2:55]C(O)=O)=[CH:49][CH:48]=4)[CH2:41][CH2:40]3)[O:37][CH2:36][CH2:35]2)=[O:33])[N:31]=1)[CH3:26].[CH3:61][O:62][CH:63]([O:69][CH3:70])[CH2:64][NH:65][CH2:66][CH2:67][CH3:68].C(N(CC)CC)C>ClCCl>[CH3:61][O:62][CH:63]([O:69][CH3:70])[CH2:64][N:65]([CH2:66][CH2:67][CH3:68])[C:4](=[O:8])[CH2:55][CH2:54][O:53][CH2:52][CH2:51][C:50]1[CH:49]=[CH:48][C:47]([CH2:46][CH2:45][N:42]2[CH2:41][CH2:40][C:38]3([O:37][CH2:36][CH2:35][N:34]([C:32]([C:30]4[N:31]=[C:27]([CH2:25][CH3:26])[S:28][CH:29]=4)=[O:33])[CH2:39]3)[CH2:44][CH2:43]2)=[CH:60][CH:59]=1

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 12555585N-(2,2-Dimethoxyethyl)propan-1-amineHCID 58168480HCID 58168480, Verbindung

Produkt 1

HCID 58168471HCID 58168471, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

HATU (0.33 g) was added to a solution of 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid [Example 3, step e] in (0.50 g), N-(2,2-dimethoxyethyl)propan-1-amine [Liebigs Annalen der Chemie 1979, 11, 1818]. (0.12 g) and triethylamine (0.56 mL) in dichloromethane (5 mL) at 0° C. under nitrogen, and the mixture stirred at ambient temperature for 2 hours. The mixture was washed with water, the organic phase was separated, dried, filtered and concentrated in vacuo to afford the subtitled compound as an orange oil. Yield 0.43 g.

Aufarbeitung

  1. washThe mixture was washed with water
  2. customthe organic phase was separated
  3. customdried
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cac7b7f36a504a6da45f41a63fb73550
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476265B2

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