Hydrochloric Acid → 1-Acetyl-4-hydrazinopiperidine hydrochloride

HRID 44649Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 44649
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10](C(OC(C)(C)C)=O)[NH:11]C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:26]>CO.O1CCOCC1>[ClH:26].[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([NH:10][NH2:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 57444162Di-tert-butyl 1-(1-acetylpiperidin-4-yl)hydrazine-1,2-dicarboxylate

Produkt 1

HCID 574441611-Acetyl-4-hydrazinopiperidine hydrochlorideAusbeute 77 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

32 g (0.09 mol) of di-tert-butyl 1-(1-acetylpiperidin-4-yl)hydrazine-1,2-dicarboxylate were dissolved in 300 mL of methanol and 30 mL of HCl 4 M in dioxane were added. The mixture was stirred at room temperature overnight. The solvent was then evaporated and the residue crystallized from ethanol, giving 14 g (77% yield) of the title compound.

Aufarbeitung

  1. customThe solvent was then evaporated
  2. customthe residue crystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-4c19543251a94dd78179e188c0c71ec5
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541429B2

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