Methanol → Methyl 4-(methylamino)butanoate hydrochloride

4-(Methylamino)butanoic acid hydrochloride (22.1 g, 144 mmol) was dissolved in methanol (560 mL), thionyl chloride (42 mL) was added under ice cooling, and then the mixture was stirred at room temperature for 24 hours. After the reaction was completed, the solvent was evaporated under reduced pressure, and the resulting white solid was washed with a mixed solvent of dichloromethane (30 mL) and hexane (300 mL) to give the title compound (21.2 g; yield, 88%) as a white solid.

1. customthe solvent was evaporated under reduced pressure
2. washthe resulting white solid was washed with a mixed solvent of dichloromethane (30 mL) and hexane (300 mL)

ORD-Eintrag

ord-2b7605e2551d4aa8967d8a6ebf346012

Quelldatensatz

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08476253B2