1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 86663477, Verbindung

HRID 446599

Reaktionsgleichung

Reaktionsgleichung von HRID 446599
[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11]([OH:13])=O)[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][N:15]([CH2:23][CH2:24][CH2:25][NH:26][CH3:27])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19].Cl.C(N=C=NCCCN(C)C)C>>[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11]([N:26]([CH3:27])[CH2:25][CH2:24][CH2:23][N:15]([CH3:14])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:19])[CH3:20])=[O:13])[CH:8]=[CH:7][C:5]=2[N:6]=1

Komponenten

4

Edukt 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 17868293tert-butyl N-methyl-N-(3-(methylamino)propyl)carbamateHCID 457896282-Bromo-1,3-benzothiazole-6-carboxylic acid

Produkt 1

HCID 86663477HCID 86663477, VerbindungAusbeute 77,1 %

Versuchsvorschrift

The compound (100 mg, 0.387 mmol) obtained in Example 93a, tert-butyl methyl[3-(methylamino)propyl]carbamate (78 mg, 0.387 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (89 mg, 0.464 mmol) were used to give the title compound (132 mg; yield, 77%) as a yellow oily substance according to the method described in Example 89b.

Quellen und Nachweise

ORD-Eintrag
ord-6e12ee81a834406eab9991c10baa900a
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476253B2

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