1-(2-{Methyl[N-(4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)-beta-alanyl]amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate → 1-{2-[(N-{4-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methy)amino]propyl}(methyl)carbamoyl]phenyl}-beta-alanyl)(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

HRID 446606Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 446606
[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[C:6]([N:8]1[CH2:12][C@@:11]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][C:25]3([C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][C@@H:28]3[O:36][CH2:37][C:38](O)=[O:39])[CH2:24][CH2:23]2)([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:10][CH2:9]1)=[O:7].[C:50]1([C:90]2[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57](=[O:89])[O:58][CH:59]1[CH2:64][CH2:63][N:62]([CH2:65][CH2:66][N:67]([CH3:88])[C:68](=[O:87])[CH2:69][CH2:70][NH:71][C:72]2[CH:77]=[CH:76][C:75]([C:78](=[O:86])[N:79]([CH3:85])[CH2:80][CH2:81][CH2:82][NH:83][CH3:84])=[CH:74][CH:73]=2)[CH2:61][CH2:60]1>>[C:50]1([C:90]2[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57](=[O:89])[O:58][CH:59]1[CH2:60][CH2:61][N:62]([CH2:65][CH2:66][N:67]([C:68](=[O:87])[CH2:69][CH2:70][NH:71][C:72]2[CH:73]=[CH:74][C:75]([C:78](=[O:86])[N:79]([CH2:80][CH2:81][CH2:82][N:83]([C:38](=[O:39])[CH2:37][O:36][C@@H:28]3[C:25]4([CH2:26][CH2:27][N:22]([CH2:21][CH2:20][C@:11]5([C:13]6[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=6)[O:10][CH2:9][N:8]([C:6](=[O:7])[C:5]6[CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=[C:3]([C:2]([F:49])([F:1])[F:48])[CH:4]=6)[CH2:12]5)[CH2:23][CH2:24]4)[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29]3)[CH3:84])[CH3:85])=[CH:76][CH:77]=2)[CH3:88])[CH2:63][CH2:64]1

Komponenten

3

Edukt 2

HCID 666717151-(2-{Methyl[N-(4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)-beta-alanyl]amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamateHCID 86663420{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetic acid

Produkt 1

HCID 469284421-{2-[(N-{4-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methy)amino]propyl}(methyl)carbamoyl]phenyl}-beta-alanyl)(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamateAusbeute 64 %

Versuchsvorschrift

The compound (119 mg, 0.17 mmol) obtained in Example 1j and the compound (98 mg, 0.16 mmol) obtained in Example 94c were used to give the title compound (130 mg; yield, 64%) as a white solid according to the method described in Example 11e.

Quellen und Nachweise

ORD-Eintrag
ord-efbcce36e16a490a97a6e8bf84ed6884
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476253B2

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