Benzyl {6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}{-4-[methyl(N-methyl-beta-alanyl)amino]phenyl}carbamate → Benzyl {6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(4-{[N-({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)-N-methyl-beta-alanyl](methyl)amino}phenyl)carbamate

HRID 446612Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 446612
[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[C:6]([N:8]1[CH2:12][C@@:11]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][C:25]3([C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][C@@H:28]3[O:36][CH2:37][C:38](O)=[O:39])[CH2:24][CH2:23]2)([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:10][CH2:9]1)=[O:7].[C:50]1([C:102]2[CH:107]=[CH:106][CH:105]=[CH:104][CH:103]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57]([O:59][CH:60]1[CH2:65][CH2:64][N:63]([CH2:66][CH2:67][N:68]([CH3:101])[C:69](=[O:100])[CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][N:75]([C:86]2[CH:91]=[CH:90][C:89]([N:92]([CH3:99])[C:93](=[O:98])[CH2:94][CH2:95][NH:96][CH3:97])=[CH:88][CH:87]=2)[C:76](=[O:85])[O:77][CH2:78][C:79]2[CH:84]=[CH:83][CH:82]=[CH:81][CH:80]=2)[CH2:62][CH2:61]1)=[O:58]>>[C:50]1([C:102]2[CH:107]=[CH:106][CH:105]=[CH:104][CH:103]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57]([O:59][CH:60]1[CH2:61][CH2:62][N:63]([CH2:66][CH2:67][N:68]([CH3:101])[C:69](=[O:100])[CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][N:75]([C:86]2[CH:87]=[CH:88][C:89]([N:92]([C:93](=[O:98])[CH2:94][CH2:95][N:96]([C:38](=[O:39])[CH2:37][O:36][C@@H:28]3[C:25]4([CH2:26][CH2:27][N:22]([CH2:21][CH2:20][C@:11]5([C:13]6[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=6)[O:10][CH2:9][N:8]([C:6](=[O:7])[C:5]6[CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=[C:3]([C:2]([F:49])([F:1])[F:48])[CH:4]=6)[CH2:12]5)[CH2:23][CH2:24]4)[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29]3)[CH3:97])[CH3:99])=[CH:90][CH:91]=2)[C:76](=[O:85])[O:77][CH2:78][C:79]2[CH:80]=[CH:81][CH:82]=[CH:83][CH:84]=2)[CH2:64][CH2:65]1)=[O:58]

Komponenten

3

Edukt 2

HCID 66671493Benzyl {6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}{-4-[methyl(N-methyl-beta-alanyl)amino]phenyl}carbamateHCID 86663420{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetic acid

Produkt 1

HCID 86663479Benzyl {6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(4-{[N-({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)-N-methyl-beta-alanyl](methyl)amino}phenyl)carbamateAusbeute 76,7 %

Versuchsvorschrift

The compound (111 mg, 0.16 mmol) obtained in Example 1j and the compound (133 mg, 0.17 mmol) obtained in Example 97e were used to give the title compound (180 mg; yield, 73%) as a white solid according to the method described in Example 11e.

Quellen und Nachweise

ORD-Eintrag
ord-be4a726dd30745f8adb2d29739570451
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476253B2

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