(6-Methylpyridin-2-yl)methanol hydrochloride → 2-(Chloromethyl)-6-methylpyridine

HRID 446816

Reaktionsgleichung

Reaktionsgleichung von HRID 446816
[ClH:1].[CH3:2][C:3]1[N:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][CH:4]=1>O=S(Cl)Cl>[Cl:1][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([CH3:2])[N:8]=1

Komponenten

3

Edukt 1

HCID 18413908(6-Methylpyridin-2-yl)methanol hydrochloride

Produkt 1

HCID 765462-(Chloromethyl)-6-methylpyridineAusbeute 70,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24386Thionyl ChlorideLösungsmittel

Versuchsvorschrift

A solution of (6-methylpyridin-2-yl)methanol hydrochloride (1.0 g, 0.008 mol) in SOCl2 (3 mL) was stirred at RT for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene and the resulting residue was filtered and dried in vacuo to afford 2-(chloromethyl)-6-methylpyridine (800 mg, 63%) as a light brown solid.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was azeotroped with toluene
  4. filtrationthe resulting residue was filtered
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d56dcbc7c9984717852394e78b9c4ed7
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481534B2

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