Ethanol → Diethyl 2-nitro-4-benzoylphenylmalonate

HRID 4472

Reaktionsgleichung

Reaktionsgleichung von HRID 4472
[Na].C(O)C.[C:5]([O:13][CH2:14][CH3:15])(=[O:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8].Cl[C:17]1[CH:30]=[CH:29][C:20]([C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:22])=[CH:19][C:18]=1[N+:31]([O-:33])=[O:32]>C(Cl)Cl>[N+:31]([C:18]1[CH:19]=[C:20]([C:21](=[O:22])[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:29]=[CH:30][C:17]=1[CH:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:5]([O:13][CH2:14][CH3:15])=[O:12])([O-:33])=[O:32]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 7761Diethyl MalonateHCID 417434-Chloro-3-nitrobenzophenoneHCID 5360545Sodium

Produkt 1

HCID 13408230Diethyl 2-nitro-4-benzoylphenylmalonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of sodium ethoxide, formed by reacting 4.6 g. (0.2 mole) of sodium metal with 200 ml. of ethanol, at 0° C. was added 32 g. (0.2 mole) of diethyl malonate followed by 26.1 g. (0.1 mole) of 4-chloro-3-nitrobenzophenone. The mixture was allowed to stir at room temperature for 2 hours and was then poured into 400 ml. of ice cold 2N hydrochloric acid and 300 ml. of methylene chloride. The organic layer was separated, dried over magnesium sulfate and concentrated to an oil. The residual oil was induced to crystallize by trituration with hexane containing trace amounts of diisopropyl ether, 34.75 g., m.p. 68°-70° C. The sample was further purified by trituration with hot hexane-diisopropyl ether, 30.84 g. (80% yield).

Aufarbeitung

  1. additionwas then poured into 400 ml
  2. customThe organic layer was separated
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated to an oil
  5. customto crystallize by trituration with hexane containing trace amounts of diisopropyl ether, 34.75 g
  6. customThe sample was further purified by trituration with hot hexane-diisopropyl ether, 30.84 g

Quellen und Nachweise

ORD-Eintrag
ord-c0dad1d0d168495ea764fd1fd6e209c1
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04725616

Verknüpfte Notizen

Wird geladen…