4-(4-Bromophenyl)-4-hydroxypiperidine → 4-(4-Bromophenyl)-5,6-dihydropyridine

HRID 447310Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 447310
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2(O)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 1

HCID 939114-(4-Bromophenyl)-4-hydroxypiperidine

Produkt 1

HCID 667303604-(4-Bromophenyl)-5,6-dihydropyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 4-(4-bromophenyl)piperidin-4-ol (500 mg, 1.95 mmol) in TFA (4 mL) was heated to 90° C. for 2 h. The crude reaction mixture was concentrated under reduced pressure to dryness, to give a yellow solid (460 mg, used without further purification). MS ESI 237.9 [M+H]+, calcd for [C11H12BrN+H]+ 238.02.

Aufarbeitung

  1. customThe crude reaction mixture
  2. concentrationwas concentrated under reduced pressure to dryness
  3. customto give
  4. customa yellow solid (460 mg, used without further purification)

Quellen und Nachweise

ORD-Eintrag
ord-1f142ae88e924643a4ffa0b9b094f33b
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481533B2

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