Dichloromethane → HCID 20689421, Verbindung

HRID 447538Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 447538
[Br:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C(Cl)Cl.C(O)(C(F)(F)F)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)=[CH:20][CH:21]=1

Komponenten

4

Edukt 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 10760574Tert-butyl 4-(4-bromobenzyl)piperidine-1-carboxylate

Produkt 1

HCID 20689421HCID 20689421, VerbindungAusbeute 93 %

Versuchsvorschrift

To a solution of tert-butyl 4-(4-bromobenzyl)piperidine-1-carboxylate (780 mg, 2.2 mmol) in CH2Cl2 (15 mmol), was added TFA (0.5 mL) and the mixture was stirred at rt for 1 h. The solvent was removed in vacuo and the residue dissolved into CH2Cl2 (50 mL), washed with NaOH (0.1 M, 10 mL), brine (10 mL), dried over MgSO4 and concentrated to dryness to give the title compound as a beige solid (520 mg, 93%).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue dissolved into CH2Cl2 (50 mL)
  3. washwashed with NaOH (0.1 M, 10 mL), brine (10 mL)
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-77409a7a9ef44bada38ec9add6197bec
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481525B2

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